TUhjnbcbe - 2021/7/13 6:51:00
StudyofCellularAginginaCohortofPatientswithHeartFailureHigh?Blood?PressCardiovascPrevOriginalarticleEarlyRecent,Dec14,./s---x本文由“天纳”临床学术信息人工智能系统自动翻译点击文末“阅读原文”下载本文PDFIntroductionCellularsenescenceandfibrosisareimportantphenomenainthedevelopmentofheartfailure(HF).Theseprocessesarecloselyrelatedtotelomericlength(TL).细胞衰老和纤维化是心力衰竭发生发展的重要现象。这些过程与端粒长度（TL）密切相关。AimToassesscellularsenescenceinHFthroughthestudyofTLinperipheralbloodmononuclearcells(PBMCs).通过外周血单个核细胞（PBMCs）TL的研究，评价HF患者的细胞衰老。MethodsUsingreal-timePCR,TLwasmeasuredinPBMCsfrom20patientsdiagnosedwithHF,agedbetween51and77?years(50%males).TenpatientshadHFwithreducedejectionfraction(HFrEF)andtenhadpreservedEF(HFpEF).TLwasmeasuredin20healthycontrolsmatchedbyageandgender.Obtainedvalueswere