最新白癜风的治疗方法 https://m-mip.39.net/baidianfeng/mipso_4249431.htmlTheAWAKE-HFStudy:Sacubitril/ValsartanImpactonDailyPhysicalActivityandSleepinHeartFailureAmJCardiovascDrugsOriginalResearchArticleEarlyRecent,Sept26,./s---y本文由“天纳”临床学术信息人工智能系统自动翻译点击文末“阅读原文”下载本文PDFBackgroundAWAKE-HFevaluatedtheeffectoftheinitiationofsacubitril/valsartanversusenalaprilonactivityandsleepusingactigraphyinpatientswhohaveheartfailurewithreducedejectionfraction(HFrEF).在射血分数降低的心力衰竭（HFrEF）患者中，AWAKE-HF评估了沙库巴曲/缬沙坦与依那普利对活动和睡眠的影响。MethodsInthisrandomized,double-blindstudy,patientswithHFrEF(n?=?)wererandomlyassignedtosacubitril/valsartanorenalaprilfor8?weeks,followedbyan8-weekopen-labelphasewithsacubitril/valsartan.Primaryendpointwaschangefrombaselineinmeanactivitycountsduringthemostactive30?min/dayatweek8.Thekeysecondaryendpointwaschangeinmeannightlyactivitycounts/minutefrombaselinetoweek8.KansasCityCardiomyopathyQuestionnaire-23(KCCQ-23)wasanexploratoryendpoint.在这项随机、双盲研究中，HFrEF患者（n?＝?）被随机分配给沙库巴曲/缬沙坦或依那普利8周，然后用沙库巴曲/缬沙坦进行8周的开放标记期。主要终点是在第8周最活跃的30分钟/天期间，平均活动计数较基线有所变化。关键的次要终点是从基线检查到第8周的平均夜间活动次数/分钟的变化。堪萨斯城心肌病问卷-23（KCCQ-23）是一个探索性终点。ResultsTherewerenodetectabledifferencesbetweengroupsingeometricmeanratioofactivitycountsduringthemostactive30?min/dayatweek8