北京治白癜风专科医院 https://wapjbk.39.net/yiyuanfengcai/yyjs_bjzkbdfyy/TODAY今日发布BasicResCardiolMar01,:(2)今日发布01篇（共计03篇）CurrAtherosclerRepFeb01,:22(2)今日发布01篇CurrCardiovascRiskRepFeb01,:14(2)今日发布01篇CardiovascDiabetolDec01,:19(1)今日发布05篇（共计06篇）JIntervCardElectrophysiolEarlyRecent,Jan07,今日发布01篇BMCCardiovascDisordDec01,:20(1)今日发布01篇StrokeEarlyRecent,Jan08,今日发布01篇CirculationResearchEarlyRecent,Jan08,今日发布01篇JAHAJan21,:9(2)今日发布03篇RECOMMEND推荐阅读01BMX抑制血栓早期PAR1介导的内皮细胞通透性和血管渗漏CirculationResearchresearch-articleZhaoLi,MingzhuYin,etc.1小时前Rationale:BonemarrowkinaseontheXchromosome(BMX)ishighlyexpressedinthearterialendotheliumfromtheembryonicstagetotheadultstageinmice.Itisalsoexpressedinmicrovesselsandthelymphaticsinresponsetopathologicalstimuli.However,itsroleinendothelialpermeabilityandsepsisremainsunknown.小鼠X染色体上的骨髓激酶（BMX）在胚胎期至成年期的动脉内皮细胞中高表达。它也表达在微血管和淋巴管对病理刺激的反应。然而，它在内皮通透性和脓毒症中的作用尚不清楚。Objective:WeaimedtodelineatethefunctionofBMXinthrombin-mediatedendothelialpermeabilityandthevascularleakagethatoccurswithsepsisincecalligationandpuncture(CLP)models.本研究旨在探讨BMX在凝血酶介导的盲肠结扎穿孔（CLP）模型内皮通透性和脓毒症血管渗漏中的作用。MethodsandResults:TheCLPmodelwasappliedtowild-typeandBMXknockoutmicetoinducesepsis.Meanwhile,theelectriccell-substrateimpedancesensingassaywasusedtodetecttrans-endothelialelectricalresistanceinvitroandthemodifiedMilesassaywasusedtoevaluatevascularleakageinvivo.WeshowedthatBMXlosscausedlunginjuryandinflammationinearlyCLP-inducedsepsis.DisruptionofBMXincreasedthrombin-mediatedpermeabilityinmiceandculturedendothelialcells(ECs)by2-3-fold.TheexpressionofBMXinmacrophages,neutrophils,plateletsandlungepithelialcellswasundetectable