0721国际期刊速递丨今日热点慢性心 [复制链接]

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TODAY今日发布CATHETERCARDIOINTEEarlyRecent,July20,今日发布02篇EchocardiographyEarlyRecent,July20,今日发布05篇JAMAINTERNMEDEarlyRecent,July20,今日发布11篇JAMAEarlyRecent,July20,今日发布02篇CirculationResearchEarlyRecent,July21,今日发布01篇EClinicalMedicineEarlyRecent,July21,今日发布01篇CirculationEarlyRecent,July21,今日发布01篇CirculationJuly21,3)今日发布18篇JAHAJuly21,:9(14)今日发布24篇（共计40篇）ClinicalCardiologyEarlyRecent,July21,今日发布01篇RECOMMEND推荐阅读01慢性心力衰竭机械负荷和循环支持下非糖代谢在心肌恢复中的作用Circulationresearch-articleRachitBadolia,DineshK.A.Ramadurai,etc.2小时前等13用户推荐阅读本文Background:Significantimprovementsinmyocardialstructureandfunctionhavebeenreportedinsomepatientswithadvancedheartfailure(termedresponders[R])followingleftventricularassistdevice(LVAD)–inducedmechanicalunloading.Thistherapeuticstrategymayaltermyocardialenergymetabolisminamannerthatreversesthedeleteriousmetabolicadaptationsofthefailingheart.Specifically,ourpreviousworkdemonstratedapost-LVADdissociationofglycolysisandoxidative-phosphorylationcharacterizedbyinductionofglycolysiswithoutsubsequentincreaseinpyruvateoxidationthroughthetricarboxylicacidcycle.Theunderlyingmechanismsresponsibleforthisdissociationarenotwellunderstood.Wehypothesizedthattheaccumulatedglycolyticintermediatesarechanneledintocardioprotectiveandrepairpathways,suchasthepentose-phosphatepathwayand1-carbonmetabolism,whichmaymediatemyocardialrecoveryinR.据报道，在左心室辅助装置（LVAD）诱导的机械负荷后，一些晚期心力衰竭患者（称为应答者[R]）的心肌结构和功能有了显著改善。这种治疗策略可能会改变心肌能量代谢，从而逆转衰竭心脏的有害代谢适应。特别是，我们之前的研究表明，LVAD后糖酵解和氧化磷酸化的解离，其特征是诱导糖酵解，而随后丙酮酸通过三羧酸循环氧化增加。导致这种分离的基本机制还不清楚。我们假设累积的糖酵解中间产物被导入心脏保护和修复途径，如磷酸戊糖途径和1-碳代谢途径，这些途径可能介导R。Methods:WeprospectivelyobtainedpairedleftventricularapicalmyocardialtissuefromnonfailingdonorheartsaswellasRandnonrespondersatLVADimplantation(pre-LVAD)andtransplantation(post-LVAD).Weconductedproteinexpressionandmetaboliteprofilingandevaluatedmitochondrialstructureusingelectronmicroscopy.我们前瞻性地从无病供体心脏中获得了成对的左心室心尖部心肌组织，以及左心室移植术前（LVAD前）和移植后（LVAD后）的R和无反应者。我们进行蛋白质表达和代谢物分析，并用电子显微镜评估线粒体结构。Results:Westernblotanalysisshowssignificantincreaseinrate-limitingenzymesofpentose-phosphatepathwayand1-carbonmetabolisminpost-LVADR(post-R)as